A 42-year old woman was referred for a metabolic evaluation after two episodes of kidney stones.
Her laboratory results revealed a normal anion-gap metabolic acidosis, a marked hypocitraturia (0,6 mmol/24h; norm 1,6-4,5) and a urinary pH of 7,0 confirming renal tubular acidosis (RTA). We identified topiramate, our patient's medication for migraine, as the cause of the RTA. Topiramate, a carboanhydrase inhibitor leads to RTA of a mixed (proximal and distal) type and thus significantly increases the risk for kidney stones.
Written by:
Gerber L, Wüthrich RP, Mohebbi N. Are you the author?
Klinik für Nephrologie, Universitätsspital Zürich, Switzerland.
Reference: Praxis (Bern 1994). 2012 May 9;101(10):665-8.
PubMed Abstract
PMID: 22565558
Article in German.
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