They followed 15 healthy subjects in a 3 phase, randomized crossover metabolic study comparing these three types of protein, with 1 week to each phase. Each phase contained a standard diet with equivalent protein content from each of the sources, as well as 3L of fluid daily. One week was spent after each phase as a washout period. Serum chemistries were collected on the last 3 mornings of each phase, and a 24-hour urine was collected on the last 2 days of the phase. They found that the fish diet resulted in the highest levels of urinary uric acid, while the beef diet resulted in the lowest levels; both findings being significant. Urinary uric acid levels exceeded normal levels for all 3 phases. No differences were noted for calcium, citrate, oxalate, sodium, or urinary pH among the diets.
Accordingly, it may be beneficial for stone formers to limit their intake of animal protein, particularly fish.
Best Poster
Presented by Sara Best, MD, et al. at the American Urological Association (AUA) Annual Meeting - May 14 - 19, 2011 - Walter E. Washington Convention Center, Washington, DC USA
Reported for UroToday by Phillip Mucksavage, MD, Department of Urology, University of California, Irvine.
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