To determine the association between kidney stone history and predicted 10-year risk of atherosclerotic cardiovascular disease events in a nationally representative US adult sample without existing cardiovascular disease.
This was a cross-sectional study of the 2017-2020 National Health and Nutrition Examination Survey that included a nationally representative sample of 3,842 adults aged 40-79 free from cardiovascular disease. Kidney stone history was assessed through self-reporting. The 10-year risk of an atherosclerotic cardiovascular disease event was predicted using the American College of Cardiology/American Heart Association (ACC/AHA) Pooled Cohort Equations.
The weighted prevalence of kidney stones was 12.2% (95% CI: 10.5% to 14.1%). In unadjusted analysis, the odds of borderline or higher (≥5%) atherosclerotic cardiovascular disease risk were higher in stone formers (odds ratio=1.56; 95% CI 1.01-2.40; P=0.046). This association persisted after adjustment for demographics and clinical covariates (adjusted odds ratio=1.57; 95% CI=1.02 to 2.43; P=0.04). A significant interaction by biological sex was identified (p=0.002), with excess risk conferred by kidney stones in men but not women.
Kidney stone history was independently associated with increased 10-year predicted atherosclerotic cardiovascular disease event risk, with excess risk observed among men but not women. Intensified cardiovascular disease screening may be warranted among stone formers given their increased cardiovascular risk.
Urology. 2024 Aug 31 [Epub ahead of print]
Samir Bhattacharyya, Larry E Miller, Silvia Proietti, Khurshid R Ghani, Ben H Chew, Naeem Bhojani
Health Economics and Market Access, Boston Scientific, Marlborough, MA, USA. Electronic address: ., Department of Biostatistics, Miller Scientific, Johnson City, TN, USA. Electronic address: ., Department of Urology, San Raffaele Hospital, Milan, Italy. Electronic address: ., Department of Urology, Michigan Medicine, University of Michigan, Ann Arbor, USA. Electronic address: ., Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address: ., Division of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada. Electronic address: .