Objective: To determine the feasibility and develop a robotic technique for intracorporeal implantation of a biodegradable tubular scaffold seeded with adipose-sourced smooth muscle cells (Neo-Urinary-Conduit® (NUC), Tengion®) which, when implanted as a conduit for urinary diversion, facilitates regeneration of native-like neo-urinary tissue.
Material and Methods: Robotic NUC implantation was performed in two fresh male cadavers. The greater omentum was widely detached from the greater curvature of the stomach, in preparation for final wrapping of the conduit. Bilateral ureters were mobilized for implantation. The NUC, with two pre-created ureteral openings, was inserted into the abdomen. Bilateral, stented uretero-NUC anastomoses were created. The NUC was circumferentially wrapped with the pre-dissected omentum, exteriorized through the abdominal wall, and maturated.
Results: Both procedures were successfully completed intracorporeally. Operative time for NUC implantation was 90 and 100 min, respectively. Examination of gross anatomy showed no injury to other organs. There was no omental kinking, rotation, eversion, or stripping from the NUC. Bilateral stents were confirmed to be in situ with the proximal coil in the kidney. Uretero-NUC anastomoses and omentum were tension-free. The entire NUC, including its distal edge and posterior aspect, was circumferentially wrapped 360 degrees.
Conclusion: We demonstrated the feasibility and developed a robotic technique for intracorporeal implantation of a biodegradable regenerative urinary conduit. This study serves as the foundation for the robotic surgical technique prior to the clinical application.
Written by:
Abreu AL, Azhar RA, Berger A, Chopra S, Marien A, Santomauro M, Satkunasivam R, Sun Y, Aron M, Ukimura O, Desai M, Gill IS. Are you the author?
University of Southern California - USC, USC Institute of Urology, 1441 Eastlake Avenue, Suite 7416, Los Angeles, California, United States.
Reference: J Endourol. 2014 May 8. Epub ahead of print.
doi: 10.1089/end.2014.0271
PubMed Abstract
PMID: 24810844
UroToday.com Endourology Section
