Fosfomycin is a potential option for vancomycin-resistant enterococcus (VRE) infections despite limited in vitro and clinical data.
In this study, 32 VRE isolates from renal transplant patients with urinary stent infections were susceptible to fosfomycin, daptomycin, and linezolid and resistant to amoxicillin, minocycline, and nitrofurantoin based on their MIC50s and MIC90s. Fosfomycin was bacteriostatic at 0.5 to 16× the MIC (32 to 2,048 μg/ml); synergy occurred when fosfomycin was combined with daptomycin (2.8 to 3.9 log10 CFU/ml kill; P < 0.001) or amoxicillin (2.6 to 3.4; P < 0.05). These combinations may be potent options to treat VRE urinary infections pending investigation of clinical efficacy.
Written by:
Descourouez JL, Jorgenson MR, Wergin JE, Rose WE. Are you the author?
Pharmacy Practice Division, University of Wisconsin School of Pharmacy, Madison, Wisconsin, USA.
Reference: Antimicrob Agents Chemother. 2013 Mar;57(3):1518-20.
doi: 10.1128/AAC.02099-12
PubMed Abstract
PMID: 23263002
UroToday.com Endourology Section
