Division of Urology, Department of Clinical and Biological Sciences, University of Turin, "San Luigi" Hospital, Regione Gonzole 10, 10043, Orbassano, Turin, Italy.
To analyse the surgical margins status of prostatic glands, resected by laparoscopic radical prostatectomy (LRP) for prostate cancer, and to correlate it with biochemical free survival rate (BFSR).
Data were collected prospectively from 405 patients undergoing LRP from 2000 to 2009 at a single institution. Patients undergoing neoadjuvant and/or adjuvant therapy were excluded from the study. Three hundred patients matched all the criteria: 232 of these had negative surgical margins (NSM) and 68 positive surgical margins (PSM). The median follow-up was 62 months. PSM were classified based on the following: (a) the number of margins, monofocal and multifocal, (b) the location, apical or non-apical and (c) the extension, ≤ 2.8 mm or >2.8 mm. These data were then entered into a multivariate analysis.
Overall BFSR rate was 67.6% in PSM group and 88.8% in NSM group (P < 0.001). We registered a HR of 3.78 in multivariate analysis (P < 0.001). In terms of the extension, BFSR in univariate survival analysis was 77.8% in ≤ 2.8 mm PSM and 38.9% in >2.8 mm PSM (P = 0.003), with a HR of 5.68 (P = 0.011) in multivariate analysis. BFSR was 59% for apical margins and 77% for non-apical margins (P = 0.038). In monofocal margins, BFSR was 73%, while 53% in multifocal (P = 0.014).
We recommend careful evaluation of patients with PSM following LRP, especially if they are more than 2.8 mm, and in these cases, adjuvant therapy should be considered after radical surgery.
Written by:
Porpiglia F, Fiori C, Manfredi M, Grande S, Poggio M, Bollito E, Papotti M, Scarpa RM. Are you the author?
Reference: World J Urol. 2011 Jun 23. Epub ahead of print.
doi: 10.1007/s00345-011-0711-2
PubMed Abstract
PMID: 21698420
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