Kidney-sparing surgery (KSS) for upper tract urothelial cancer (UTUC) has gained increasing interest recently. However, there is limited contemporary data regarding the role of KSS in ureteral urothelial carcinoma. Therefore, we investigated the survival outcomes of ureteral urothelial carcinoma after KSS from a large prospective international UTUC registry.
The Clinical Research Office of the Endourology Society-Urothelial Carcinomas of the Upper Tract (CROES-UTUC) Registry included UTUC patients who received KSS or radical nephroureterectomy (RNU) between 2014 and 2019. In this study, we included patients with ureteral UTUC only. Study outcomes included overall survival (OS), cancer-specific survival (CSS), upper tract recurrence-free survival (RFS), intravesical RFS, progression-free survival (PFS), and metastasis-free survival (MFS). Propensity score matching (PSM) was performed to balance the tumour features' differences between groups.
Of 391 patients with ureteral UTUC, 309 (79.0%) received RNU, and 82 (21.0%) received KSS by ureteroscopy with laser ablation (n=28) or segmental resection (n=54). After PSM, there were no differences in OS (p=0.525), CSS (p=0.487), upper tract RFS (p=0.147), intravesical RFS (p=0.989), PFS (p=0.617), and MFS (p=0.336) between KSS and RNU. Both ureteroscopic ablation and segmental resection had similar OS, CSS, intravesical RFS, PFS, and MFS with RNU. Proximal ureteral UTUC had worse OS and CSS outcomes than other tumour locations following segmental resection.
In patients with ureteral UTUC, no significant differences in long-term survival outcomes were observed between KSS and RNU. Proximal ureteral UTUC had worse survival outcomes over other tumour locations following segmental resection.
Journal of endourology. 2024 May 17 [Epub ahead of print]
Kang Liu, Hongda Zhao, Chi-Fai Ng, Jeremy Y C Teoh, Maria Pilar Laguna, Jean Jmch de la Rosette
The Chinese University of Hong Kong, Surgery, Hong Kong, Hong Kong; ., The Chinese University of Hong Kong, Surgery, Hong Kong, Hong Kong; ., The Chinese University of Hong Kong, Surgery, 4/F Prince of Wales Hospital, Shatin, Hong Kong, Hong Kong, N/A., Prince of Wales Hospital, Surgery, 30-32 Ngan Shing Street, Shatin, New Territories., Hong Kong, Hong Kong; ., Medipol Mega University Hospital , Urology , Otoyulu Goztepe Cikisi 1, Istanbul, Bagcilar, Turkey, 34214., Amsterdam UMC - Locatie AMC, biomedical engineering, merbiergdreef 9, 1105 AZ, Amsterdam, Amsterdam, Netherlands, 1105 AZ.