To compare tissue trauma between Retropubic Radical Prostatectomy and Robotically Assisted Laparoscopic Radical Prostatectomy by inflammatory mediators. Serum samples from 40 patients submitted to RALP and 20 patients submitted to RRP were withdrawn at four different time points. The cytokines IL-4, IL-8, IL-6, IL-1B, IL-10 and TNF-α were detected using ELISA/Multiplex assays and xMAP-Luminex®. With both techniques, IL-10 and IL-6 were higher in T4 than in T1-T3 (p = 0.001). IL-10 and IL-6 were higher in T4 in open surgery than in robotic surgery (p = 0.000 and p = 0.001, respectively). Compared with both groups, IL-6 and IL-10 were higher in T4 in open surgery than in robotic surgery. Thus, we can postulate that RALP causes less tissue trauma than classical RRP, as indicated by the more limited increase in inflammatory mediators such as IL-6 and IL-10.
Journal of robotic surgery. 2020 Oct 03 [Epub ahead of print]
Denise Quinto, Sabrina T Reis, Lucca Juvele Zampolli, Ruan Pimenta, Vanessa R Guimarães, Nayara I Viana, Gabriel A Dos Santos, Mario P Gimenez, Katia R Leite, Hamilton Zampolli, José Arnaldo S da Cruz, Miguel Srougi, Carlo C Passerotti
Center for Robotic Surgery, Hospital Alemão Oswaldo Cruz, São Paulo, 01327-001, Brazil., Laboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Av. Dr. Arnaldo 455, 2° andar, sala 2141 - Cerqueira César, São Paulo, SP, 01246-903, Brazil. ., Laboratory of Medical Investigation (LIM55), Urology Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), Av. Dr. Arnaldo 455, 2° andar, sala 2141 - Cerqueira César, São Paulo, SP, 01246-903, Brazil.