EAU 2018: Urinary microbiota in premenopausal women with recurrent uncomplicated lower urinary tract infections (2010-2015)
In her bacteriological study, 333 premenopausal women with a long history of LUTI during a 6-year period were divided into 3 groups chronologically (2010-2011, 2012-2013, 2014-2015). In all 3 cases, patients experienced at least 3 LUTIs and self-medicated with varying antibiotics. All patients were administered bacteriological urine tests to examine the bacteria present in their urine.
A significant increase of occurrence frequency of enterobacteria was observed. Within this group, E. coli was shown to decrease, while Klebsiella spp. exhibited a reliable increase, and Proteus spp. varied widely. However, no significant differences in frequency were noticed in gram-positive flora, specifically coagulase-negative staphylococci (CNS) and non-clostridial anaerobic bacteria (NAB).
In conclusion, enterobacteria were determined to have an increased role in the etiology of LUTI in premenopausal women. However, due to the decrease in occurrence frequency of E. coli, Dr. Naboka reiterates that this difference is related to the wide-use of antibiotics, many of which generally target E. coli.
Speaker: Dr. Naboka
Authors: Naboka Y., Kogan M., Gudima I., Dzhalagonia K., Chernitskaya M.
Written by: Whitney Zhang, Department of Urology, University of California-Irvine, at the 2018 European Association of Urology Meeting EAU18, 16-20 March, 2018 Copenhagen, Denmark