EAU 2018: Comparison Of Efficacy Of Intravesical Hyaluronic Acid Alone And In Combination With Oral Chondroitin Sulfate In Patients With Bladder Pain Syndrome
For the study, 37 patients, all women, were randomly stratified into HA (n=19) and HA+oCs (n=18) treatment groups. In the HA group, hyaluronate NA viscoelastic solution (Urolife®) was injected in the patients weekly for 6 weeks, while the HA+oCs group also received the weekly injections in addition to oral chondroitin sulfate (Urolife® capsules). Patients were evaluated before treatment and one week after treatment using a visual analogue pain scale (VAS), interstitial cystitis symptom index (ICSI), interstitial cystitis problem index (ICPI), and frequency of urination/nocturia.
From the patient data compiled, it was observed that HA+oCs group experienced a lower VAS, ICSI, ICPI, and frequency score suggesting better response to pain syndrome and an improved 24h frequency. Therefore, it was concluded that combination of HA+oCs is superior to HA alone in relieving BPS/IC symptoms in short-term follow up of 24 hours. However, due to the limited amount of data comparing the different GAG therapies, Dr. Aboya suggested that further assessment with long-term follow up is needed.
Speaker: Dr. Aboyan
Authors: Aboyan V., Aboyan I., Zin'kovskaya O., Mirkin Y.
Written by: Whitney Zhang, Department of Urology, University of California-Irvine, at the 2018 European Association of Urology Meeting EAU18, 16-20 March, 2018 Copenhagen, Denmark