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- Tom Farrington and Alicia Morgans discuss how to engage best with patients about clinical trials and clinical care. Tom emphasizes that patients are simply not aware of clinical trials that are available and that these trials present " another treatment option ". Clinical trials that offer randomization to the standard of care or the standard of care plus the additional treatment option being eval...
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- Carmel Pezaro discusses her recent move from Australia to Sheffield, England with Alicia Morgans in which they discuss the similarities in the needs of men with prostate cancer in the two countries where men need treatments, support from their families, and their providers. There are differences where in Australia they embrace new technologies such as PSMA PET which is not available in the UK. The...
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- Kim Chi, MD discusses the first results from TITAN, A phase 3 randomized, placebo-controlled, double-blind study of apalutamide (APA) versus placebo (PBO) in men with metastatic hormone-sensitive prostate cancer (mHSPC), with Michael Morris, MD, and Alicia Morgans, MD. TITAN was designed to accrue patients with prior treatment for localized prostate cancer or prior docetaxel for mHSPC were allowed...
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- Wassim Abida provides a current roadmap for molecular genetic subtyping in prostate cancer with the main goal of targeting the right therapies for progressing patients. The one clear indication for molecular testing at this point is in the identification of MSI-high prostate cancer because pembrolizumab is approved for this indication. Investigational PARP inhibitors (poly (ADP-ribose) polymerase...
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- World Trade Center responders with prostate cancer showed signs that inflammation was activated in the prostate after exposure to dust from the World Trade Center site, possibly causing chronic inflammation that contributed to their cancer, according to a study by Mount Sinai researchers in Molecular Cancer Research in June. Reference: WTC Research . 2019. Video. https://www.youtube.com/watch?v=m5...
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- Morgan Roupret joins Charles Ryan to speak about the increase in bladder cancer in younger individuals and in particular younger women. Dr. Roupret explains the clinical issues that challenge clinicians when managing younger bladder cancer patients. Biographies: Morgan Roupret, MD, PhD, Professor of Urology, Sorbonne Université, Paris (UPMC), ESOU chairman, Paris, France Charles J. Ryan, MD , the...
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- Phillip Koo joins Neal Shore to discuss radium 223 for treating men with metastatic castration-resistant prostate cancer. Radium-223 has improved overall survival (OS) and reduced symptomatic skeletal events (SSE) in patients with metastatic castration-resistant prostate cancer (mCRPC) and bone metastases (ALSYMPCA trial). The survival benefit and the safety and tolerability profile of radium-223...
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- Morgan Roupret sits down with Charles Ryan and discusses the quality of life of patients undergoing urinary diversion after radical cystectomy. Dr. Roupret highlights findings in the subject including properties of a well-functioning neobladder, the volume of a neobladder the day after surgery, and how the experience and technique of the operating urologist may factor into the patient’s quality of...
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- Brenda Martone discusses the nurse practitioner's role in assessing and managing immune related complications and toxicities associated with checkpoint inhibitors with Alicia Morgans. Brenda notes that immune related reactions may occur months after a single dose of the immune checkpoint inhibitors pembrolizumab, atezolizumab, and durvalumab. Immune-related reactions may include diarrhea and colit...
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- Sipuleucel-T (Provenge ® ) has been FDA approved since 2010 in men with asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). The IMPACT (Immunotherapy for Prostate AdenoCarcinoma Treatment), was a randomized, double-blind, placebo-controlled study of 512 men with metastatic, hormone-refractory prostate cancer. Initially, the targeted patients were those wi...
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