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- Oliver Sartor speaks with Michael Schultz about advances in radiopharmaceuticals for cancer treatment. Dr. Schultz discusses the advantages of using alpha-particle emitters, particularly lead-212, for targeted cancer therapy. He explains the rationale behind choosing lead-212, including its short half-life and the ability to use lead-203 for imaging. Dr. Schultz addresses distribution challenges a...
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- Oliver Sartor speaks with Philip Kantoff about the future of radiopharmaceuticals in cancer treatment. Dr. Kantoff discusses the rationale behind using antibody-based approaches for PSMA-targeted therapies, particularly with actinium-225, citing better cancer cell retention and reduced toxicity to salivary and lacrimal glands compared to small molecules. He highlights promising early results from...
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- Oliver Sartor speaks with Emanuele Ostuni about ARTBIO’s focus on radiopharmaceuticals, particularly lead-212. Dr. Ostuni explains ARTBIO’s choice of lead-212 for its short half-life, which better matches the biological half-lives of targeting ligands. He discusses the manufacturing and distribution challenges associated with short-lived isotopes and outlines ARTBIO’s approach to developing a netw...
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- Ashish Kamat interviews Felix Guerrero-Ramos about a European Urology Oncology review on novel treatments for non-muscle-invasive bladder cancer (NMIBC). Dr. Guerrero-Ramos presents an overview of emerging therapies across different risk categories of NMIBC, focusing on intravesical and systemic approaches. He highlights FDA-approved treatments for BCG-unresponsive disease and ongoing trials for B...
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- Andrea Miyahira discusses with Irene Casanova-Salas and Joaquin Mateo a Cancer Cell publication on using circulating tumor extracellular vesicles (EVs) to monitor metastatic prostate cancer evolution. The researchers describe their novel method for analyzing both DNA and RNA from EVs in patient plasma samples. They highlight the advantages of EV analysis over traditional ctDNA, including the abili...
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- Sam Chang interviews Jason Brown about research on disparities in bladder cancer mortality between urban and rural settings from 2000 to 2020. Dr. Brown presents findings showing a significant decline in bladder cancer mortality in urban areas, particularly large metropolitan centers, while rates remain unchanged in rural areas. The study uses CDC data and Joinpoint Regression analysis to identify...
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- Sam Chang interviews Joseph Jacob about a registry trial examining the effectiveness of Jelmyto (UGN-101) in treating ureteral tumors. Dr. Jacob presents data from a retrospective study involving 23 patients across 15 high-volume centers in the US. The study explores the use of Jelmyto beyond its initial indication in renal pelvis tumors, focusing on its application in ureteral tumors. Dr. Jacob r...
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- Rashid Sayyid and Zach Klaassen review the 2024 NCCN prostate cancer guideline updates focusing on treatment-related bone loss in patients on androgen deprivation therapy (ADT). They emphasize the importance of addressing bone health due to increased fracture risk associated with ADT. The speakers outline a comprehensive approach to bone health management, including risk assessment using the FRAX...
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- Rashid Sayyid and Zach Klaassen review the NCCN prostate cancer guideline updates regarding the prevention of symptomatic skeletal-related events in bone metastatic CRPC patients. They discuss the efficacy and safety profiles of denosumab and zoledronic acid, highlighting key clinical trials that have shaped current recommendations. The speakers emphasize the importance of considering dosing frequ...
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- At the CAncer or Not Cancer: Evaluating and Reconsidering GG1 prostate cancer (CANCER-GG1?) Symposium, Scott Eggener advocates for reclassifying Grade Group 1 prostate cancer, arguing that it should no longer be called cancer. He concludes by stressing the importance of focusing on individual and population health in this discussion, encouraging a respectful and productive dialogue among various s...
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