Subjects were administered a questionnaire at baseline and again at 1- and 3-months. Frailty was assessed at baseline using the timed up and go (TUG) test (whereby a TUG time of ³12 seconds was considered to be slow, or frail). Response to treatment was assessed using the overactive bladder symptom score (OABSS) and the OAB-q SF (both bother and HRQOL subscales). Information on side effects/adverse events was also collected. Mixed effects linear modeling was used to model changes in outcomes over time both within and between groups.
There was a total of 45 subjects (22 pharmacotherapy;12 onabotulinumtoxinA;11 sacral neuromodulations) enrolled in the study,40% (N=18) of whom had a TUG ³12 seconds. There were no differences in responses to baseline OAB questionnaires between TUG groups (all p-values >0.05). Both TUG groups demonstrated improvement in OAB symptoms over time and there were no statistically significant differences in these responses per group (all p-values >0.05). Similar trends were found for both OAB-q bother and OAB-q HRQOL questionnaire responses. Side effects and adverse events were comparable between groups (p’s>0.05).
They concluded that adults > 60 years of age starting second- and third-line treatments for OAB, regardless of TUG time, demonstrated improvement in OAB symptoms at 3 months. They also suggested that frail older adults receive comparable benefit and similar rates of side effects compared to less frail individuals, supporting the use of second- and third-line OAB treatments in properly selected older adults.
Presented by: Anne Suskind, MD, MS, FACS, Associate Professor of Urology, The University of California, San Francisco
Co-Authors: Casey Kowalik, MD2, Kathryn Quanstrom1, John Boscardin, PhD1, Shoujun Zhao, PhD1, Stuart Reynolds, MD3, Kavita Mishra, MD1, Emily Finlayson, MD, MS1
Author Affiliation:
1. Department of Urology, The University of California, San Francisco, UCSF
2. The University of Kansas Medical Center,
3. The Vanderbilt University Medical Center
Written by: Bilal Farhan, MD, Clinical Instructor, Female Urology and Voiding Dysfunction, Department of Urology, University of California, Irvine @Bilalfarhan79 at the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction Winter Meeting, SUFU 2019, February 26 - March 2, 2019, Miami, Florida