#AUA15 - Clinical stage I renal mass upstaging to pathological T3a disease portends a worse prognosis only when sinus fat invasion is present - Session Highlights

NEW ORLEANS, LA USA (UroToday.com) - Upstaging at the time of surgery in cT1 localized RCC cases is a rare but known phenomenon. Sumit De and colleagues evaluated outcomes of patients who had upstaging due to sinus vs perirenal fat invasion.

auaSeven hundred ninety-two patients were identified from the prospectively maintained Fox Chase Cancer Center Kidney Cancer Database who had surgery between 2001 and 2014; 92 of these patients developed disease progression/ recurrence. Pathological upstaging due to perirenal (n=31) or sinus fat invasion (n=21) was identified but only correlated with disease progression in patients with sinus fat invasion in both univariable and multivariable regression. The relationship of oncologic outcome and upstaging due to renal vein invasion in comparison to sinus fat invasion was not evaluated.

The authors’ conclusion is that not all pT3a lesions behave the same.

Presented by Sumit De at the American Urological Association (AUA) Annual Meeting - May 15 - 19, 2015 - New Orleans, LA USA

Fox Chase Cancer Center, Philadelphia, PA USA

Reported by Phillip Abbosh, MD, PhD, medical writer for UroToday.com