NEW ORLEANS, LA USA (UroToday.com) - Michael Vacchio presented work from his group at Memorial Sloan Kettering Cancer Center evaluating genomic alterations as they relate to presurgical clinical features. Preliminary work from his group shows that imaging and genomic alterations are indeed related, and this study looked at a validating cohort and more genomic alterations.
Pretreatment imaging, RNAseq, tumor target gene sequencing, and pathological data from 130 institutional patients and 62 TCGA patients were used to generate relationships. Two radiologists and one pathologist reviewed clinical data without prior knowledge of genomic data. They found that 5q amplification was associated with renal sinus contact, SETD2 mutation was associated with tumor necrosis and renal vein invasion, mutation of VHL/BAP1/TP53 was associated with high grade disease, and 9q loss was associated with higher stage.
This type of work may increase the accuracy of preoperative risk nomograms since some of these alterations can be correlated to patient outcome.
Presented by Michael Vacchio at the American Urological Association (AUA) Annual Meeting - May 15 - 19, 2015 - New Orleans, LA USA
Memorial Sloan Kettering Cancer Center, New York, NY USA
Reported by Phillip Abbosh, MD, PhD, medical writer for UroToday.com