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- Sam Chang host Mario de Angelis to discuss a study on trimodal therapy (TMT) for urothelial and non-urothelial invasive bladder cancer. Dr. De Angelis presents findings from a SEER database analysis of over 5,000 patients treated with TMT. The study reveals that TMT use has increased for organ-confined urothelial carcinoma but decreased for non-urothelial cases. For organ-confined disease, patient...
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- Zach Klaassen speaks with Brent Rose about advances in bladder-sparing therapies for localized bladder cancer. Dr. Rose highlights the surprising underutilization of chemo-radiation in bladder cancer treatment, despite its established role in other cancers and the significant risks and quality of life issues associated with cystectomy. He underscores the efficacy of chemo-radiation, drawing on dat...
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- Sam Chang interviews Neal Shore about the KEYNOTE-992 trial comparing immunotherapy combined with chemoradiation to standard trimodality therapy for muscle-invasive bladder cancer. Dr. Shore explains that the trial evaluates Pembrolizumab with chemoradiation versus placebo with chemoradiation in patients suitable for bladder-sparing approaches. He emphasizes the importance of offering bladder-pres...
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- Sam Chang hosts Sophia Kamran to discuss her recent research on bladder cancer. The study, titled "Genomic Tumor Correlates of Clinical Outcomes Following Organ-sparing Chemoradiation Therapy for Bladder Cancer," focuses on genomic characterizations that could predict outcomes for bladder preservation strategies. Dr. Kamran details the use of genomic and transcriptomic profiling to guide treatment...
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- In a multi-faceted discussion among medical experts, the focus is on optimizing bladder cancer treatment strategies, particularly the interplay between radiation, immunotherapy, and surgical interventions like TURBT. Dr. Brian Baumann and others emphasize the importance of tailoring treatments to patient risk factors and discuss preliminary data from trials like the SWOG/NRG, indicating tolerabili...
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- In his talk, Brian Baumann explores radiation therapy for local recurrence and oligometastatic bladder cancer, emphasizing the importance of adjuvant radiation in preventing local recurrence, particularly in patients with locally advanced T3 and T4 disease or node-positive cases. He reviews key studies supporting adjuvant radiotherapy and highlights that modern techniques like IMRT are well-tolera...
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- At the 2023 Bladder Cancer Advocacy Network (BCAN) Think Tank Monika Joshi delivers an enlightening talk on the subject of node-positive non-metastatic bladder cancer, a new area that only started to be defined in 2017. She covers the emphasis on the recent classification of this type of bladder cancer, the EA8185 cooperative group study, and the challenges and considerations regarding lymph node...
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- At the 2023 Bladder Cancer Advocacy Network (BCAN) Think Tank meeting Scott Delacroix elucidates on the role of radiation therapy in treating non-muscle invasive bladder cancer, focusing on its potential and his personal experiences with trimodality therapy for muscle-invasive bladder cancer. He discusses a Single Arm Phase 2 study (RTOG 0926) and its outcomes, and presents data on combining immun...
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- Leslie Ballas, Jason Efstathiou, and Alexandre Zlotta discuss the study Radical Cystectomy Versus Trimodality Therapy for Muscle-Invasive Bladder Cancer: A Multi-Institutional Propensity Score Matched and Weighted Analysis'. The research suggests TMT is as effective as radical cystectomy, exhibiting no significant disparity in five-year survival rates. This implies TMT could be a valuable alternat...
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- Rashid Sayyid and Zach Klaassen discuss a study published in Lancet Oncology titled “Radical Cystectomy versus Trimodality Therapy for Muscle-Invasive Bladder Cancer: A Multi-Institutional Propensity Score Matched and Weighted Analysis.” The study compared radical cystectomy and trimodality therapy (TMT) for patients with Muscle-Invasive Bladder Cancer. The authors found that radical cystectomy, t...
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