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- In this discussion with Andrea Miyahira, Akash Patnaik illuminates the role of the Rb gene in severe forms of prostate cancer and its intriguing interaction with the immune system. His team's research uncovers that Rb loss is associated with lower immune infiltration and a higher presence of immunosuppressive genes. Patnaik's team further observes an unexpected upregulation of the STING gene, typi...
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- In a discussion with Andrea Miyahira, Himisha Beltran discusses her team's research on Prostate-Specific Membrane Antigen (PSMA) heterogeneity and regulation in metastatic prostate cancer. The study, led by Martin Bakht, explores the varied levels of PSMA expression in metastases of androgen receptor-positive prostate cancer, as well as the regulation of PSMA in AR-negative and neuroendocrine pros...
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- Michael Haffner and Andrea Miyahira discuss a JCI Insight publication, "Reversible Epigenetic Alterations Mediate PSMA Expression Heterogeneity in Advanced Metastatic Prostate Cancer". The study investigated PSMA expression heterogeneity in advanced metastatic prostate cancer, finding that the expression pattern of PSMA varies significantly between different metastatic sites and patients. They als...
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- Heather Cheng and Andrea Miyahira discuss the GENTleMEN study, which explored the feasibility of an internet-based, cost-free genetic testing program for men with metastatic prostate cancer. The study aimed to provide genetic testing to patients with advanced disease by removing barriers to access and cost and was launched in 2016 after research suggested that 25% of metastatic prostate cancer tum...
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- Andrew Armstrong joins Andrea Miyahira in discussing a retrospective analysis of the prospective multicenter PROPHECY trial of men with metastatic castration-resistant prostate cancer (mCRPC) treated with abiraterone or enzalutamide seeking to develop a liquid biopsy using circulating tumor cells (CTCs) that they can associate with outcomes in men with mCRPC and ultimately apply that to a PSMA-tar...
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- Andrea Miyahira and Akash Patnaik discuss a Clinical Cancer Research publication that explores a new approach to disrupt immuno metabolic pathways within an aggressive variant form of prostate cancer. Dr. Patnaik provides background on the current state of metastatic castrate-resistant prostate cancer and the biologic underpinnings of aggressive variant prostate cancer, focusing on the PTEN PI3-ki...
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- Asmaa El-Kenawi shares her research on the effects of nutrient availability in the tumor microenvironment as part of her Prostate Cancer Foundation (PCF) Young Investigator Award. Her work centers around understanding the dynamic interactions of cancer cells with immune cells, normal cells, and physical factors, like oxygen and pressure, and micronutrients within the cancerous environment. She aim...
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- Jacob Berchuck shares his insights with Alicia Morgans about his groundbreaking research on racial disparities in prostate cancer between African American and European American men. Dr. Berchuck's study explores the androgen receptor cistrome and its differing effects on prostate cancer biology. He identifies increased androgen receptor binding at genes associated with lipid metabolism in African...
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- Alexander Wyatt delves into his team's cutting-edge research on circulating tumor DNA (ctDNA) in relation to prostate cancer. This innovative study, published in Nature, elucidates the diversity and potential utility of ctDNA, found in the bloodstream, for understanding disease progression and characteristics. By developing algorithms to differentiate various ctDNA populations, they shed light on...
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- Charles Ryan and Isra Elhussin engage in an enlightening conversation about the disparities in cancer genomic profiling between African and European ancestries. Dr. Elhussin's pioneering research investigates how genetic ancestry and specific gene mutations, notably SPOP mutations more prevalent in those of African ancestry, influence prostate cancer subtypes and treatment responses. Her study hig...
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