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- In this conversation, Andrea Miyahira hosts Gerhardt Attard to discuss a publication in Nature Communications, specifically focusing on the genomic architecture of lethal prostate cancer clones. The study from Dr. Attard’s team examines alterations in the androgen receptor (AR) and their association with resistance to treatments like abiraterone and enzalutamide. Dr. Attard highlights the intrapat...
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- Amina Zoubeidi delves into her research on prostate cancer lineage plasticity. She highlights her team’s paper, "ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer," published in Cell Reports. Dr. Zoubeidi explains the concept of lineage plasticity and its role in therapy resistance, particularly post-hormone therapy. She introduces th...
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- Nima Sharifi presents a published paper that investigates the role of testosterone in prostate cancer. Over a decade-long study, Dr. Sharifi's team discovered that a subset of men undergoing radical prostatectomy have unusually high levels of periprostatic testosterone, linked to worse clinical outcomes such as PSA recurrence or salvage radiation therapy. This surprising finding challenges convent...
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- Daniela Brina discusses her team’s paper on prostate cancer pathways and the role of myeloid-derived suppressor cells (MDSCs) in tumor progression. The study delves into the extracellular interaction between prostate cancer and MDSCs, employing polysome profiling techniques across different genetic backgrounds. Dr. Brina and her team identified specific ligands and receptors that facilitate the re...
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- Andrea Miyahira hosts a discussion with Karen Sfanos about her group's research on Proliferative Inflammatory Atrophy (PIA) of the prostate, published in the Journal of Pathology. The paper, titled "Club-Like Cells in Proliferative Inflammatory Atrophy of the Prostate," investigates the relationship between PIA and prostate cancer, focusing on the abnormal proliferation of PIA cells resembling lun...
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- Andrea Miyahira hosts June Chan and Rebecca Graff to discuss their research on post-diagnostic health behaviors and their relation to prostate cancer progression and mortality. They reflect on two papers published in the British Journal of Cancer, examining factors such as smoking, obesity, physical activity, and BMI, and their impact on lethal prostate cancer. The conversation emphasizes that mai...
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- Brandon Mahal discusses a large-scale, retrospective analysis involving nearly 12,000 patients, exploring comprehensive genomic profiling and treatment patterns in advanced prostate cancer across different ancestries. The study reveals significant variances in incidence and mortality by race and genomic ancestry, emphasizing a greater burden on men of African ancestry. It exposes how these men rec...
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- Andrea Miyahira hosts Tamara Lotan to discuss the paper, "Predicting Prostate Cancer Molecular Subtype with Deep Learning on Histopathologic Images." Dr. Lotan details the collaborative work with Angelo De Marzo's lab at Johns Hopkins and AIRA MATRIX, an AI deep learning company in India. The study aims to predict underlying molecular subtypes of prostate cancer using deep learning algorithms on h...
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- In this discussion, Andrea Miyahira speaks with Ping Mu about his group's paper. The research focuses on the role of SYNCRIP in controlling APOBEC-driven mutagenesis in prostate cancer. Dr. Mu explains that the loss of SYNCRIP leads to a break in the mechanism controlling this mutagenesis driver, resulting in prostate cancer gaining resistance to AR therapy. The conversation highlights the tumor h...
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- Burcu Darst explores her team's study on developing polygenic risk scores for prostate cancer in men of African and European ancestry. This study aims at addressing health disparities, and uses a large, diverse prostate cancer GWAS involving over 230,000 men from various populations. The results indicate that men in the top polygenic risk score decile are three to four times more likely to have pr...
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