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- Christopher Barbieri joins Matthew Cooperberg for a discussion about the molecular biology of localized prostate cancer. Dr. Barbieri explains how the underlying molecular and genomic features that separate prostate cancer subtypes can be studied using DNA sequencing and RNA sequencing. The conversation covers predictive markers including DECIPHER, PAM50, genomic mutations, and oncogenic drivers....
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- Rob Reiter and Alicia Morgans discuss the use of MRI and active surveillance in prostate cancer treatment. Dr. Reiter explains how MRI is used to improve proper patient selection for active surveillance. He also discusses how he was an early adopter of MRI and how he incorporates an MRI-guided biopsy program in his practice. In conclusion, Dr. Reiter and Dr. Morgans agree it’s important to note th...
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- Matthew Cooperberg warmly welcomes Sanoj Punnen, to discuss the complexities surrounding the prediagnostic space for men with elevated PSA levels and the challenging decision of whether to pursue a biopsy. Dr. Punnen highlights the limitations of PSA as a screening tool, emphasizing the emerging role of liquid biopsy markers and MRI in this area. They both recognize the significance of integrating...
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- Alicia Morgans sits down with Neal Shore to discuss the ENACT trial, which investigates the use of enzalutamide in patients starting on active surveillance for prostate cancer. Dr. Shore explains that the trial aims to address the underutilization of active surveillance and explores whether enzalutamide can prevent upstaging of histopathology and reduce positive biopsies. The study, which was not...
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- Kosj Yamoah joins Alicia Morgans in discussing a gray area in the management of biochemical recurrence. Kosj Yamoah presented on who needs early salvage radiotherapy and who needs adjuvant radiotherapy at the 2022 Advanced Prostate Cancer Consensus Conference (APCCC) Meeting. The APCCC addresses key areas of prostate cancer management where there are uncertainties or areas where there is a lack of...
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- Daniel Lin joins Alicia Morgans in highlighting a guideline-directed practical course on how to use genomics in clinical practice. Dr. Lin was part of the instructional course faculty at the AUA annual meeting. The learning objectives of this course include a discussion on the research studies that led to the approval of genomic testing for prostate cancer, ordering appropriate genomic testing bas...
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- Matthew Cooperberg joins Alicia Morgans in a conversation on genomic risk classification in localized prostate cancer. They discuss the risk stratification of prostate cancer and where the use of this is most valuable. Dr. Cooperberg highlights this topic in terms of two basic categories of markers: the pre-diagnostic in terms of liquid tests and post-diagnostic settings. Biographies: Matthew Coop...
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- James Eastham and Stephen Boorjian join Alicia Morgans in a conversation on AUA Guidelines focused on localized prostate cancer. The guidelines provide a framework to have a conversation with a patient about their individual situation involving risk assessment, not only from the cancer standpoint but also from the treatment standpoint. These guidelines provide the framework of what physicians shou...
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- Laurence Klotz joins Phillip Koo at the 13th International Uro-Oncology Congress in São Paulo, Brazil in a discussion on Active Surveillance (AS), High-intensity focused ultrasound (HIFU), and focal therapy in Latin America and developing countries. There are challenges with active surveillance in developing countries that might not have formal prostate cancer screening programs, a lack of resourc...
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- The Scientific Director at the Society of Oncology and Hematology from del Cesar, Columbia, Ray Manneh Kopp joins Phillip Koo bringing a global perspective to a discussion on the novel approaches in the management of high-risk prostate cancer. They discuss the diagnosis criteria currently being used, the novelties in the diagnosis, and adjuvant alternatives in this disease. Biographies: Ray Manneh...
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