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- Urothelial carcinomas of the upper urinary tract (UTUCs) are rare, with poorer stage-for-stage prognosis than urothelial carcinomas of the urinary bladder. No international consensus exists on the benefit of adjuvant chemotherapy for patients with UTUCs after nephroureterectomy with curative intent. The POUT (Peri-Operative chemotherapy versus sUrveillance in upper Tract urothelial cancer) trial a...
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- Seth Lerner, MD, FACS, presents updated information on the United States Federal Drug Administration (FDA) approval of Jelmyto (UGN-101) for low-grade upper tract urothelial carcinoma (LG-UTUC), and the results of the OLYMPUS trial, Optimized DeLivery of Mitomycin for Primary UTUC Study (Olympus) . LG-UTUC is rare and previously there were few kidney-sparing options. UGN-101 is a mixture of a ther...
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- Seth Lerner and Sam Change discuss the recent phase 3 OLYMPUS study, published in The Lancet Oncology. Dr. Lerner was the principal investigator of the single-arm study which investigated the use of thermal-reversible gel mitomycin (Jelmyto) for low-grade upper tract urothelial cancer (UTUC). The study had a 59% complete response rate and thus identified and the FDA approved Jelmyto as a kidney-sp...
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- Zachary Klaassen, MD, MSc, and Christorpher Wallis, MD, Ph.D., discuss the OLYMPUS study of using UGN-101, a mitomycin-containing reverse thermal gel, for the treatment of Upper Tract Urothelial Carcinoma. The Food and Drug Administration approved mitomycin for adult patients with low-grade upper tract urothelial cancer (LG-UTUC). Efficacy determination was based on OLYMPUS, an ongoing, single-arm...
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- Alison Birtle and Surena Matin join Ashish Kamat for an educational session on the highly debated question of “should we use neoadjuvant or adjuvant therapy when it comes to upper tract urothelial carcinoma?” Dr. Birtle is the Chief Investigator of the POUT study and presents the side of adjuvant chemotherapy for the standard of care in patients with upper tract urothelial carcinoma. Dr. Matin pre...
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- Vitaly Margulis joins Ashish Kamat in a discussion on the top three developments in upper tract urothelial treatment starting with localized disease and moving onto the more advanced disease. With the difficulty in administering treatment in the upper tract, Dr. Margulis highlights intracavitary therapies, genetic changes that are prevalent in upper tract advanced disease, and the use of systemic...
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- The OLYMPUS trial, which led to the approval of Jelmyto (Mitomycin gel) for low-grade upper tract urothelial cancer (UTUC), is an open-label, single-arm, phase 3 trial that aimed to assess the safety and activity of a non-surgical treatment using instillation of UGN-101, a mitomycin containing reverse thermal gel, a kidney-sparing treatment. In this video interview with Sam Chang, Seth Lerner, the...
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- Recorded Date: April 24, 2020 Zachary Klaassen and Christopher Wallis join Alicia Morgans to discuss the management guidance released by European Urology on how to best optimize the care of patients with UTUC malignancies during the COVID-19 pandemic. In this Journal Club, Dr. Klaassen and Dr. Wallis assess the impact of delaying treatment in patients with upper tract urothelial carcinoma and disc...
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- Ashish Kamat invites Alison Birtle to share a review of a Phase III Randomized Trial of Perioperative Chemotherapy versus Surveillance in Upper Tract Urothelial Carcinoma (UTUC) POUT study. The POUT study sought to answer the basic question, does adjuvant chemotherapy reduce the risk of relapse for upper tract urothelial carcinoma (UTUC) patients who've had a potentially "curative," nephroureterec...
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- Petros Grivas hosts Matthew Galsky, Bishoy Faltas and Andrew Hsieh in a discussion about their research programs and recent findings that drive closer to providing personalized medicine in the treatments in metastatic urothelial carcinoma and upper tract urothelial cancers. Groundbreaking work is discussed in this podcast and the three platform papers that discuss this evidence in more detail are...
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