Organophosphate-Induced Delayed Neuropathy (OPIDN) is a rare neurological disorder triggered by exposure to organophosphorus compounds. These compounds exert their neurotoxic effects by impacting the nervous system, leading to systemic manifestations. Urinary system symptoms are infrequently observed in clinical settings. Currently, effective therapeutic interventions for OPIDN-related urinary symptoms are lacking. Sacral nerve modulation therapy, an FDA-approved approach for managing lower urinary tract symptoms, presents as a promising option. Herein, we present a case of OPIDN-induced lower urinary tract obstruction successfully treated with sacral nerve modulation therapy, resulting in substantial symptom relief.
A 27-year-old male patient presented with severe bilateral hydronephrosis, attributed to low bladder compliance and accompanied by a fever persisting for 6 days. The patient's medical history revealed accidental ingestion of organophosphate pesticide (Dimethoate) with no concomitant underlying diseases. In consideration of the potential for OPIDN, surgical intervention in the form of sacral neuromodulation (phase I) was undertaken. Subsequent evaluation one month post-surgery revealed notable improvements in both bladder compliance and bilateral hydronephrosis, necessitating sacral neuromodulation (phase II). Presently, following a 5-month follow-up period, the patient remains asymptomatic and in favorable health.
This patient achieved long-term relief using sacral neuromodulation.
BMC urology. 2024 Oct 04*** epublish ***
Junjie Han, Dingliang Zhao, Shuqiang Feng, Xuesong Yang, Yinchun Wang, Zhenhua Dong, Zhao Sun, Ziyuan Deng, Yi Zhang, Ranwei Li
Department of Urology, The Second Hospital of Jilin University, 4026 Yatai Avenue, Changchun, 130041, Jilin, People's Republic of China., Department of Urology II, The First Hospital of Jilin University, Changchun, 130021, Jilin, People's Republic of China., Department of Gastric and Colorectal Surgery, The First Hospital of Jilin University Changchun, Jilin, 130021, People's Republic of China., Department of Urology, The Second Hospital of Jilin University, 4026 Yatai Avenue, Changchun, 130041, Jilin, People's Republic of China. ., Department of Urology, The Second Hospital of Jilin University, 4026 Yatai Avenue, Changchun, 130041, Jilin, People's Republic of China. .