OBJECTIVE: To evaluate the long-term safety of a novel continuous infusion of ketorolac vs placebo after laparoscopic donor nephrectomy.
INTRODUCTION: Due to its immunosuppressive properties, local graft irradiation (LGI) has been proposed as a second line therapy for treatment of acute kidney rejection.
BACKGROUND: Malignancy is a common complication after renal transplantation.
A variety of therapeutic modalities are available to alter the abnormalities seen in patients with chronic kidney disease (CKD).
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease.
PURPOSE: Calcineurin inhibitors (CNI) associated nephrotoxicity remains a risk factor for long-term graft dysfunction after renal transplantation.
PURPOSE: The aim of this study is to evaluate the efficacy and safety of interventional radiology procedures in the treatment of major urological complications after kidney transplantation.
INTRODUCTION: The incidence of renal cell carcinoma (RCC) continues to rise concurrently with the increased prevalence of end-stage renal disease worldwide.
CONTEXT: The ability of a transplant recipient to accept a graft depends on the ability of immunosuppressive drugs to regulate the immune system.
Context: Indications for laparoscopic renal surgery are increasing; however benefits in adult polycystic kidney disease (APKD) remain uncertain.
Nephron sparing surgery (NSS) results in the transplanted population remain unknown because they are only presented in small series or case reports.
OBJECTIVE: To report a single-center 10-year experience of outcomes of kidney transplantation in African Americans (AAs) vs Caucasian Americans (CA) and to propose ways in which to improve kidney transplant outcomes in AAs, increased access to kidney transplantation, prevention of kidney disease, and acceptance of organ donor registration rates in AAs.
PURPOSE: Chronic allograft nephropathy (CAN) is the most common cause of kidney allograft failure.
Increasing evidence suggests that acute kidney injury (AKI) mediates a systemic response that can lead to multiple organ failure.
Ischemic conditioning is a phenomenon through which short sequences of ischemiareperfusion applied to an organ confer some degree of protection towards future ischemic insults.
INTRODUCTION: Cold storage of organs for preservation and transplantation is reaching its limits especially with extended criteria for heart beating donors and donation after cardiac death.
Ischemia reperfusion injury occurs in the kidney when blood supply is interrupted in clinical settings such as kidney transplantation or nephron sparing surgery for renal tumors.
As the impact of ischemia reperfusion injury on graft outcome is now well defined, efforts are made towards decreasing these lesions, typically through the improvement of preservation techniques.
Understanding innate immune responses and their correlation to alloimmunity after solid organ transplantation is key to optimizing long term graft outcome.
Ischemia-reperfusion injury is a complex physiological process responsible for delayed renal function or primary graft non-function, explicitly when kidney allograft are issued from expanded criteria donor.
